Direct bilirubin and indirect bilirubin are both high and need symptomatic treatment, different causes of different treatments, in the clinic, the common causes are the toxic effect of alcohol on the liver, hepatitis, biliary stones, and biliary tumors, etc., commonly used treatments are polyenophosphatidylcholine, entecavir, atropine and other medications and surgical treatment. 1. Alcohol toxicity: patients with liver function problems due to excessive alcohol consumption need to stop drinking immediately, take some hepatoprotective drugs such as polyenphosphatidylcholine under the guidance of a doctor, keep a light diet, and undergo regular checkups. 2. Hepatitis: active antiviral treatment such as entecavir, and add anti-inflammatory, antioxidant hepatoprotective drugs such as glycyrrhizic acid preparation, etc., and bed rest and symptomatic treatment are needed for severe symptoms. 3. Biliary stones: symptomatic cholelithiasis patients need to undergo surgical treatment as soon as possible, for patients with obvious pain can be added with some antispasmodic and analgesic drugs such as atropine, but also need to develop good living habits and diet. 4. Biliary tract tumors: biliary tract tumors are of high malignancy, early tumors are mainly treated by surgery, according to the actual situation of the patients after the operation with radiotherapy, and advanced tumors are mainly treated by palliative care. For patients with high direct bilirubin and indirect bilirubin, it is necessary to consult a doctor in time to find out the cause of the disease, improve the relevant examination, make a clear diagnosis and carry out standardized treatment under the guidance of the doctor.