Tadalafil does not usually affect fertility, tadalafil can treat erectile dysfunction in men, but there may be headache, flushing and other discomforts, it should be used under medical supervision. Tadalafil is a cyclic guanosine monophosphate-specific phosphodiesterase inhibitor that promotes penile erection in response to sexual stimulation, and is used clinically to treat erectile dysfunction in men. Tadalafil does not generally affect sperm production and generally has no effect on fertility. However, it should be noted that tadalafil use may cause headache, flushing, nausea, dyspepsia, myalgia back pain, persistent penile erection and other adverse reactions. And tadalafil should not be combined with nitrates such as isosorbide nitrate or guanylate cyclase stimulators such as lioresiguanide, with the risk of hypotension, and should not be used in people with a history of allergy to this drug. Tadalafil should be used under the supervision of a doctor, and if discomfort occurs, seek medical attention.