Creatinine high if belongs to the physiological increase, generally will not become uremia; if belongs to the pathologic increase in the acute kidney injury caused by the elevation, generally will not become uremia, if the chronic elevation, with the development of the disease, may become uremia. 1. Physiological elevation: generally not serious, and do not need special treatment. Such as after strenuous exercise, eating a lot of meat food, emotional stress and anxiety, etc., may lead to high creatinine, but physiological factors caused by high creatinine will not affect the renal function, affect renal excretion, most of them are not serious, it is still recommended to review regularly to assess the renal function, and will not usually become uremia. 2. Pathological increase (1) If creatinine is pathologically elevated, the excretion of renal function has been changed. If the increase is acute, such as diarrhea, infection, etc. caused by a transient increase in blood creatinine, after removing the cause of the disease and symptomatic treatment, usually can be recovered, and will not develop into uremia. (2) If the creatinine is elevated chronically, i.e. chronic renal failure, which is more serious, if not treated in time, the condition will be further aggravated and may develop into uremia. If you find creatinine elevation, we suggest you go to the regular hospital in time to find out the reason and strictly follow the doctor’s instructions to standardize the treatment.