How to read a liver fibrosis report

The liver fibrosis report card has four main indicators: type III procollagen (PCIII), laminin (LN), type IV collagen (IV-C), and hyaluronidase (HA). If the test value exceeds the normal range of the four indicators, it indicates that the patient’s liver may have fibrosis. Liver fibrosis is mainly detected by blood sampling. The normal range for type III procollagen should be less than 120 micrograms per liter, laminin 130 micrograms per liter, type IV collagen less than 75 micrograms per liter, and hyaluronidase less than 110 milligrams per liter. In general, type III procollagen increases significantly in the early stages of cirrhosis and may decrease or flatten in the later stages; laminin tends to increase significantly in hepatocellular carcinoma; type IV collagen increases in proportion to the degree of cirrhosis; and hyaluronidase tends to be significantly elevated in cirrhosis and is usually slightly elevated in acute liver disease. The test value of liver fibrosis is helpful in the detection of chronic liver disease, but if patients want to clarify the degree of liver fibrosis, they need to be diagnosed by doctors through imaging, pathology and other test data.