There are no authoritative guidelines on the duration of folic acid treatment for hyperhomocysteinemia, and most of the treatment durations mentioned in the literature are 3 to 6 months. Hyperhomocysteinemia contributes to the development of stroke and cardiovascular disease and is a risk factor for these diseases. Folic acid, vitamin B12 and vitamin B6 are commonly used in the treatment of hyperhomocysteinemia. There is no authoritative literature recommending the specific duration of medication, but it has been reported that hyperhomocysteinemia symptoms tend to normalize after 3-6 months of treatment with folic acid. However, the specific duration of medication should be decided by the clinician according to the condition of the patient and the level of blood test. In addition to medication, it is recommended to combine exercise, diet and other life adjustments. It should be noted that after the use of folic acid to appear to resist eating, nausea, abdominal distension, yellow urine and other symptoms of adverse reactions, it is recommended to temporarily stop using the drug and consult a doctor. Folic acid is contraindicated in megaloblastic anemia caused by vitamin B12 deficiency and drug allergy. The presence of hyperhomocysteinemia prompt consultation; folic acid is prohibited unauthorized use of the drug.