Dronedarone can not cure atrial fibrillation, mainly used in the treatment of paroxysmal atrial fibrillation, can improve the condition. The main role of dronedarone is antiarrhythmic, paroxysmal atrial fibrillation patients can take dronedarone orally, can maintain sinus rhythm; dronedarone’s main role is to have a maintenance effect on sinus rhythm, for the primary disease causing atrial fibrillation has no therapeutic effect, only atrial fibrillation symptomatic treatment of the drug, and not on the cause of the treatment. There are many causes of atrial fibrillation, such as coronary heart disease, hypertension, rheumatic heart disease, etc., to control the heart rate at the same time to treat the primary disease. Adverse effects of dronedarone include nausea, vomiting, diarrhea, fatigue, etc. It is contraindicated in patients who are allergic to the drug components, pregnant women, permanent atrial fibrillation, and patients with Qt intervals exceeding 550ms. When using medication, it is important to follow the doctor’s instructions, rational application of drugs, do not use drugs arbitrarily, to avoid causing serious side effects and adverse reactions.