Conservative treatment of plasma cell mastitis mainly includes anti-infective treatment and local physiotherapy, which is mainly used in the acute inflammatory stage, and surgery is often needed after inflammation control. Plasma cell mastitis occurs in the non-lactating period and is based on ductal dilatation and plasma cell infiltration. Bacterial infection is often combined with acute inflammation, and abscesses, lumps, fistulas, etc. are formed in the chronic period. For bacterial infection in the acute inflammatory stage, the main anti-infective treatment is anti-infective treatment with cefdinir, etc. In the acute stage, it can also be supplemented with local infrared rays and intermediate-frequency electric current for physical therapy. Conservative treatment is effective in the short term, but not in the long term. Surgery is the main and effective treatment for plasma cell mastitis. Surgery includes complete excision of the lesion, removal of dilated milk ducts and fistulas, which can be a more thorough treatment for plasma cell mastitis, and incision and drainage is also needed for patients with pus. It is recommended that the patient consult a doctor and choose the appropriate treatment according to the specific condition of the lesion.