The difference between adenosine monophosphate and acyclovir is mainly different indications. 1. Adenosine monophosphate: It is mainly used for the treatment of chronic hepatitis B and other viral infections such as herpes simplex, herpes zoster, genital herpes, etc. In addition, it is also effective in children’s chickenpox and hand-foot-mouth disease. Adverse effects of this drug include neuromuscular pain and joint pain, occasional thrombocytopenia, leukopenia, and pregnant women should be used with caution. 2. Acyclovir: mainly used for the treatment of genital herpes virus infection in patients with initial outbreaks; patients with recurrent herpes simplex virus infection; patients with shingles with normal immune function; patients with mild cases of immunodeficiency; patients with immunodeficiency chickenpox. Adverse effects of this drug include nausea, vomiting, diarrhea, fever, headache, etc. In addition, it should be used with caution in people with abnormal liver or kidney function and is contraindicated in pregnant women. The above drugs should be used correctly under the guidance of a doctor, and patients should not take them privately to avoid serious consequences.