Protein 38 in advanced stage of liver cancer is usually related to malnutrition, cirrhosis and destruction of liver cells caused by liver cancer, so it is necessary to replenish body nutrition and protein as soon as possible and actively treat the original disease. Liver is used to synthesize albumin, if patients have liver cancer, the protein synthesis function will be decreased, and the quantity and level of albumin in the blood will be obviously decreased, in addition to easy to combine with ascites. In addition, ascites will be easily combined with liver cancer, which will also cause protein loss and further decrease protein. When liver cancer is in the advanced stage, the tumor is relatively large, which will affect the function of liver in different degrees, and if cirrhosis is serious, there may be ascites and portal hypertension, which may lead to the decrease of albumin. In the advanced stage of liver cancer, one should pay attention to follow the doctor’s instruction to treat positively and keep the mood happy.