Gastric ulcer quadruple therapy is mainly applied to eradicate H. pylori treatment, quadruple therapy is mainly a PPI-type acid-suppressive drugs, combined with a bismuth combined with two antibiotics, the main dosing methods are as follows: a. acid-suppressive drugs can be omeprazole, pantoprazole, lansoprazole, rabeprazole, etc. choose one, the course of treatment must be sufficient, recommended twice daily, before meals or on an empty stomach; two, bismuth selected bismuth potassium citrate. It is recommended to take it before meals, twice a day; third, antibiotics are generally recommended to choose amoxicillin combined with clarithromycin, which is the most recommended anti-H. pylori two antibiotics in the guide, if amoxicillin allergy, it is recommended to choose tinidazole, levofloxacin, furazolidone, tetracycline, etc., antibiotics are generally recommended to take after meals, the course of antibiotics must be sufficient, the dose must be sufficient.