Elevated creatinine and urea nitrogen can be seen in physiological factors such as large amount of meat consumption, high protein diet, after strenuous exercise, etc. It can also be seen in pathologic factors such as renal disease, hypertension, diabetes mellitus and other diseases. 1. Physiological factors: elevated creatinine and urea nitrogen can be seen in large amounts of meat, high protein diet, after strenuous exercise, etc. Usually no special treatment is needed, and after removing the triggers, the condition can generally return to normal. 2. Pathologic factors: (1) Kidney disease: elevated creatinine and urea nitrogen suggests that the glomerular filtration function has decreased, resulting in metabolic wastes in the body can not be discharged through the kidneys, which is mainly seen in acute and chronic glomerulonephritis, nephrotic syndrome, chronic renal failure, hypertensive nephropathy, diabetic nephropathy and other renal diseases. (2) Hypertension: If the blood pressure of hypertensive patients is poorly controlled for a long time, it is easy to cause atherosclerosis, which can lead to glomerulosclerosis, resulting in increased creatinine and urea nitrogen. (3) Diabetes mellitus: If diabetic patients’ blood sugar is poorly controlled for a long time, it will lead to further deterioration of the condition, which may cause glomerulosclerosis and develop into diabetic nephropathy, resulting in elevated creatinine and urea nitrogen. If you find elevated creatinine and urea nitrogen, it is recommended to consult a doctor in time to clarify the specific cause of the disease, and then standardize the treatment under the guidance of the doctor.