Elevated alpha 1 microglobulin is not necessarily nephritis. High α1 microglobulin generally indicates that the function of proximal renal tubules is damaged, which is a relatively early and sensitive indicator of renal function damage. It is not necessarily due to nephritis or nephrotic syndrome. Clinically, prolonged diabetes mellitus, hypertension or pharmacologic renal injury can also cause high alpha1 microglobulin. At the same time, we can’t exclude the possibility of physiological elevation, such as strenuous exercise, eating a lot of high-protein food, fever, etc., need to pay attention to rest, light diet, pay attention to review. The a1 microglobulin is high, you need to consult a regular hospital, and under the guidance of a professional physician to do the relevant examination to analyze the cause of the disease, and to carry out targeted treatment.