Elevated blood creatinine includes physiological and pathological causes, among which the common pathological causes include acute kidney injury and chronic kidney disease. According to the causes of elevated creatinine, dietary modification, medication and surgery can be given to reduce creatinine. 1. Physiological causes: blood creatinine is produced by muscle metabolism, more exercise or excessive meat intake, resulting in the increase of blood creatinine production faster than the glomerular excretion rate, which will lead to the increase of blood creatinine, mainly by reducing exercise and adjusting the dietary structure to reduce blood creatinine. 2. Acute kidney injury: acute kidney injury is mainly treated by causative treatment and symptomatic treatment, the causative treatment should correct the primary disease in time, such as cardiac infarction, cardiac insufficiency, renal stone, etc.; symptomatic treatment is mainly diuretic, blood pressure lowering, potassium lowering, calcium supplement, phosphorus lowering, correcting acidosis and so on, which can reduce the blood creatinine’s effect through the treatment of kidney injury. 3. Chronic kidney disease: including dietary adjustment and drug treatment. For diet, high quality and low protein diet should be adopted, and the daily protein intake per kilogram of body weight is 0.6-0.8 grams. Drug treatment includes antihypertensive therapy, controlling proteinuria, and correcting renal anemia. When kidney injury is caused by diseases such as kidney stones, ureteral stones, renal vein thrombosis, etc., the primary disease can be treated by surgery, and the blood creatinine may drop and slowly return to normal. It is recommended to go to the hospital in time when the blood creatinine is found to be elevated to find out the cause and follow the doctor’s instructions for treatment.