Patients with hypothyroidism may experience gastric upset due to the slowing of gastrointestinal motility as a result of insufficient thyroid hormone production. Hypothyroidism is a generalized metabolic syndrome caused by hypothyroidism or thyroid hormone resistance due to various reasons. Most hypothyroidism has an insidious onset and lacks specificity in early symptoms. In the progressive stage, symptoms such as fatigue, chills, loss of appetite, lethargy, anemia, and mucous edema may occur. In patients with hypothyroidism, due to the lack of thyroid hormones, there will be a slowing down of gastrointestinal peristalsis, which will cause a delay in gastric emptying. As a result, stomach discomfort, such as bloating, acid reflux, lack of appetite and other discomforts will occur. Patients with hypothyroidism need to follow the doctor’s instructions for replacement therapy, such as the use of drugs such as levothyroxine sodium tablets, to maintain blood thyrotropin and thyroid hormones within the normal range. If gastrointestinal discomfort is obvious, gastrointestinal power and other drugs can be taken under the guidance of the doctor to treat the symptoms. Patients who are clearly diagnosed with hypothyroidism are advised to take medication regularly and under the guidance of a doctor and undergo regular checkups.