Clarithromycin is an antibiotic that is effective in treating H. pylori alone, but has a small efficacy effect. Clarithromycin is commonly used in combination with another antibiotic, proton pump inhibitor and bismuth to treat H. pylori, i.e. quadruple therapy. The four-combination therapy for H. pylori can obtain ideal efficacy, patients please according to their own situation, under the guidance of the doctor reasonable use of medication. Clarithromycin is mainly used for infections caused by sensitive bacteria, such as nasopharyngeal infections, lower respiratory tract infections, skin and soft tissue infections, acute otitis media, Mycoplasma pneumoniae pneumoniae, Chlamydia trachomatis-induced urethritis and cervicitis, legionella infections, and can also be used in combination with other drugs for the treatment of Mycobacterium avium infections, Helicobacter pylori infections. Adverse reactions to clarithromycin include oral odor, abdominal pain, diarrhea, nausea, vomiting, headache, transient elevation of serum aminotransferase, drug rash, urticaria, Stevens-Johnson disease, hepatotoxicity, and Clostridium difficile which can cause pseudomembranous enterocolitis. In addition, it is contraindicated in people who are allergic to clarithromycin or macrolides, pregnant and lactating women, severe hepatic impairment, water-electrolyte disorders, patients taking terfenadine. It is contraindicated in patients with cardiac disease, including arrhythmia, bradycardia, prolonged Q-T interval, ischemic heart disease, congestive heart failure, etc. The use of the drug in children under 6 months has not been determined. If you need to use Clarithromycin for the treatment of Helicobacter pylori, it is recommended to consult a professional doctor and follow the doctor’s instructions to regulate the use of medication.