Postoperative complications after major thyroidectomy mainly include the following points: 1, postoperative blood seepage from the surgical wound or because of long-term tumor compression, thyroid nodule compression leads to tracheal collapse, which affects respiration and thus causes respiratory distress and even asphyxiation in severe cases, so postoperative need to be prepared for bedside tracheotomy bag, if necessary, need to perform tracheotomy in a timely manner. 2, the main is the damage of the superior laryngeal nerve and laryngeal return nerve. Once the superior laryngeal nerve is damaged, there may be low voice or choking on drinking water. One side of the recurrent laryngeal nerve injury usually appears hoarse, bilateral recurrent laryngeal nerve injury at the same time can cause respiratory difficulties, and even lead to the death of the patient. 3, hand and foot convulsions, usually seen in the thyroidectomy, damage to the dorsal parathyroid glands, thus causing hypocalcemia, usually need to supplement calcium. 4, for hyperthyroidism, if the patient is not enough preparation for the operation, may cause hyperthyroidism after the operation of hyperthermia crisis such as hyperthermia.