Wisdom teeth removal 48 hours blood clot loss is usually a concern, increasing the risk of dry socket syndrome from the extraction wound. Wisdom tooth removal is a more complex extraction procedure that is generally long, traumatic and slower to heal. After wisdom tooth extraction, the extraction wound is filled with blood clots, which will be mechanized at a later stage, and granulation tissue, connective tissue and epithelial tissue will gradually form, and then be gradually replaced by fibrous bone tissue, which will form bone tissue. Therefore, blood clots play a very important role in the healing process of extraction wounds. If the blood clot is dislodged 48 hours after wisdom tooth extraction, it will make the extraction wound empty and increase the chance of dry socket. Dry socket disease is histopathologically manifested as osteitis or limited osteomyelitis of the alveolar bone wall. It can usually appear 2 to 3 days after tooth extraction and is characterized by severe pain, emptiness or foul odor in the extraction socket. Wisdom tooth extraction 48 hours of blood clot shedding, should be timely consultation, by the dentist to give symptomatic treatment, in order to prevent adverse consequences.