In the World Health Organization classification of lymphoma, there is a relatively rare type of lymphoma, which is nasal extra-nodal NK/T-cell lymphoma, but this type of lymphoma is not uncommon in our country. In recent studies, nasal extra-nodal NK/T-cell lymphoma accounts for 12% of all non-Hodgkin’s lymphomas, second only to diffuse large B-cell lymphoma, and about 90% of nasal extra-nodal NK/T-cell lymphoma occurs in the nasal cavity, and other types of lymphoma, such as diffuse large B-cell lymphoma, also occur in the nasal cavity, making the nasal cavity a good site for lymphoma. Patients with nasal NK/T-cell lymphoma often present with nasal congestion on one or both sides, runny nose, nasal swelling, nasal septum perforation, hearing loss, tearing, facial swelling, and in some cases, enlarged lymph nodes in the neck. More than half of the patients will have systemic manifestations such as persistent fever, night sweats, and wasting. Patients are often diagnosed with rhinitis, sinusitis, nasal polyps, deviated nasal septum, etc., which often remain untreated and misdiagnosed for a long time. Such patients are better to visit ENT department, perform nasal CT or magnetic resonance examination in time, perform nasal mass biopsy, and undergo comprehensive examination and treatment in hematology department after pathology confirmation, which requires bone marrow examination, blood examination, PET/CT examination, etc., to clarify clinical stage and prognosis assessment, evaluate important organ function, and decide treatment plan, such as combined chemotherapy, autologous hematopoietic stem cell transplantation, radiotherapy, etc. To conclude, nasal lymphoma is not uncommon in China and requires the first visit of ENT doctors for biopsy, pathologists for confirmation and hematologists for treatment, and the cooperation of multiple doctors for early and accurate diagnosis and optimal treatment.