Amoxicillin belongs to antibiotics, mainly used for bacterial infections, epididymitis ate 10 days amoxicillin has no effect, may be due to viral infections caused by epididymitis or the use of medication is not standardized as well as drug resistance. 1. Viral orchitis: mainly caused by mumps virus, mumps virus infection leads to mumps attack. At the same time as the virus into the blood circulation, through the blood dissemination to reach the testicles, thus causing viral orchitis and epididymal inflammation, so ate 10 days of amoxicillin has no effect. 2. Unstandardized use of drugs: patients buy their own drugs to take, not in accordance with the doctor’s instructions to take, the dose is too small to achieve the therapeutic effect, so ate 10 days of amoxicillin has no effect. 3. drug resistance: long-term use of amoxicillin antibacterial drugs, for bacterial infections have lost the therapeutic effect, can not kill or inhibit bacteria and lead to eat 10 days amoxicillin no effect. If you suffer from epididymitis, it is recommended to go to the hospital in time to find out the cause of the disease, according to the cause of targeted treatment, do not buy their own medicine, so as not to aggravate the condition.