The appearance of runny nose and eyes with cold is most commonly associated with acute upper respiratory tract infection, which induces an acute attack of chronic allergic rhinitis. Generally, you can choose anti-allergy drugs, such as paracetamol, cetirizine, loratadine, montelukast, ketotifen, and also take vitamin C appropriately, which can reduce the pathological state of inflammatory secretions of the upper respiratory tract mucosa and can reduce nasal discharge and tears. In addition, for the etiology of acute infection, for example, due to bacterial infection, antibiotics can be given, choosing drugs such as clindamycin, amoxicillin and levofloxacin. In case of viral infections, ribavirin can be chosen.