Gastric cancer is one of the most common malignant tumors, ranking the third among all malignant tumors, which seriously endangers human health and has a high death rate, ranking the top among all malignant tumors in China. The early diagnosis rate of gastric cancer is low, and most of them have already entered the progressive stage when diagnosed, so the overall efficacy is poor. Even if the lesions are surgically removed, they are prone to recurrence and distant metastasis, and the 5-year survival rate is only 20% to 50%. Currently, the treatment of gastric cancer is a multidisciplinary and comprehensive treatment mainly based on surgery, while surgical resection and postoperative intravenous chemotherapy for progressive gastric cancer are not ideal. However, is it true that there is no cure for patients with progressive and advanced gastric cancer? The answer is in the negative. In our long-term clinical practice, after continuous exploration, we have recently developed preoperative regional-arterial chemotherapy (PRAC) for progressive and locally advanced gastric cancer, which has achieved excellent results and opened up a new way for the treatment of progressive and locally advanced gastric cancer. Arterial perfusion chemotherapy is administered through the femoral artery to the abdominal artery using the Seldinger method, and the main blood supply vessel in the corresponding area is selected according to the location of the tumor to inject chemotherapeutic drugs. Compared with systemic chemotherapy, it has high efficacy, low toxic side effects, low trauma, can effectively kill tumor cells, make tumor down-stage so as to obtain the opportunity of surgery, or even completely disappear, and can effectively treat and prevent liver metastasis, which greatly prolongs the survival period of patients and improves the quality of life. At present, we have successfully carried out hundreds of cases of progressive and locally advanced gastric cancer with 90% of the patients having their tumors downgraded and successfully undergoing radical surgery from unresectable to radical surgery, and more than half of the patients have their cancer cells completely disappeared. The treatment of gastric cancer has achieved unprecedented breakthrough progress. Here is the comparison of some advanced gastric cancer patients before and after arterial infusion chemotherapy, after that we will carry out more arterial chemotherapy for progressive and advanced gastric cancer to bring good news to more patients suffering from gastric cancer. Results after arterial chemotherapy for progressive and advanced gastric cancer: Gastric sinus cancer, the tumor invaded the pancreas before chemotherapy and could not be removed, after chemotherapy, the tumor was downgraded and the border with the pancreas was clear and surgically removed. Gastric cancer of the lesser curvature side with metastasis of group 3, 7 and 9 lymph nodes before chemotherapy, fused into a mass and unresectable. After chemotherapy the gastric cancer descended, the above lymph nodes were significantly reduced and surgically removed. Gastric body less curved side cancer with group 3, 7 and 9 lymph nodes metastasis before chemotherapy and fused into a mass, which could not be removed surgically. After chemotherapy, the above lymph nodes disappeared or shrunk significantly, and were removed surgically. Huge ulcerative gastric cancer with pyloric obstruction, tumor bleeding, invasion of the pancreas, and inoperable resection. After arterial chemotherapy, radical gastric cancer surgery was performed, and only the ulcer remained and the cancer cells completely disappeared.