Primary trigeminal neuralgia: Trigeminal neuralgia patients have serious subjective symptoms and severe pain, which is called the “king of pain”. There are various theories of its occurrence, such as the theory of neurodegeneration and the theory of microvascular compression. In the treatment of trigeminal neuralgia, drugs, surgery, gamma knife, nerve block and destruction have their own characteristics, of which percutaneous semilunar ganglion radiofrequency thermo-coagulation and destruction of more and more by more specialists are favored by the characteristics of safety, small side effects, less pain and so on. The key to this technique is accurate puncture, and the direction of puncture can be effectively adjusted under the imaging localization to avoid damage to the optic nerve and intracranial arteries and veins. Our department uses the Swedish Eleketa radiofrequency instrument with the imaging system, with precise temperature control, to avoid side effects to the greatest extent possible on the basis of exact efficacy. General anesthesia is used for intraoperative destruction to minimize the patient’s pain during treatment. Compared with other traditional treatment methods, it has the characteristics of exact efficacy, small trauma, fast recovery time, high safety, few complications, wide range of use, repeatability and so on, and it has clinical promotion value. Cervical spondylosis: Cervical spondylosis is divided into five categories: 1, nerve root type; 2, spinal cord type; 3, sympathetic nerve type; 4, vertebral artery type; 5, mixed type. Among them, the nerve root type has the highest incidence and is the main cause of neck and shoulder pain. It generally manifests as recurrent pain and numbness in the upper extremities of the neck and shoulders. Most of the cervical disc herniations confirmed by imaging are feasible to be treated with minimally invasive treatment, and the minimally invasive treatments commonly used in pain departments include radiofrequency thermo-coagulation and ozone ablation. This minimally invasive treatment utilizes the temperature of the radiofrequency needle and the ablative effect of drugs (ozone, collagenase, etc.) to shrink the herniated disc and relieve the compression of the nerve heel, thus achieving the purpose of treating the herniated disc. This kind of method combined with cervical epidural nerve block can rapidly relieve the edema of the nerve root and eliminate the patient’s pain at the first time, which has the characteristics of small trauma, high safety, and exact efficacy, etc. The scope of treatment is gradually expanding to the rest of the subtypes, and it is the ideal method of treating cervical disc herniation at present. Postherpetic neuralgia: Herpes zoster is caused by the varicella zoster virus, which causes skin lesions while infiltrating and destroying nerve cells, causing nerve cells to degenerate and leading to abnormal pain transmission function, resulting in abnormal pain. The severe pain that persists in the original herpes area even after the herpes zoster rash has healed is called postherpetic neuralgia (PHN). Typical types of pain include spontaneous paroxysmal pain (cutting, electric shock, sudden onset and offset), hyperalgesia or touch-induced pain (pain triggered by touching the skin), tingling pain, or hyperalgesia. The following patients are susceptible to postherpetic neuralgia: 1, people over 60 years old; 2, herpes occurs in the distribution area of the first branch of the trigeminal nerve; 3, the degree of rash is serious, especially the formation of ulcers; 4, diabetic patients; 5, people with low immunity caused by various reasons. At present, our pain department has a comprehensive treatment program for PHN, including medication and nerve block, nerve destruction, etc. Spinal cord electrical stimulation therapy can also be used when necessary. Most of the patients who seek timely treatment can obtain satisfactory results, but it is impossible to predict how long PHN will last, usually a few months, but also up to a few years, or even lifelong pain. Therefore, early diagnosis and proper treatment are key to minimizing the complexity of treating PHN. Rheumatic diseases: Rheumatic diseases mainly include ankylosing spondylitis and rheumatoid arthritis (AS and RA, respectively), which are common autoimmune diseases with erosive arthritis as the main manifestation, and the cause is unknown. These diseases can be accompanied by multi-system damage and may even lead to joint deformity and loss of function. Among them, ankylosing spondylitis mainly invades the central joints and large peripheral joints, and rheumatoid rheumatoid mainly invades the small peripheral joints. The treatment of rheumatoid diseases in the pain department adds injection therapy on the basis of conventional treatment, which has the characteristics of fast effect and high drug concentration in target organs, and has clinical promotion value. In the last decade, with the application of biological agents, a new dawn has been brought to patients with such diseases.