What is hand-foot syndrome: Hand-foot syndrome, also known as palm-to-toe sensory loss erythema syndrome, is one of the common adverse reactions to antineoplastic drugs such as capecitabine. The first symptoms are itching of the palms and soles of the feet, congestion of the palms, fingertips and soles of the feet, followed by painful sensation at the end of the fingers/toes, erythema and tension of the skin of the hands/feet, dullness of sensation, numbness, roughness and cracking of the skin, a few patients may have cut finger-like skin breakage, blisters, desquamation, peeling, exudation, or even ulceration, and secondary infection, patients may be unable to walk due to severe pain, and serious cases may lose the ability to live Patients may be unable to walk due to severe pain, and in severe cases may lose the ability to take care of themselves.