Itchy lower bile duct cancer can take antihistamines such as loratadine, bile acid chelating drugs such as colesevelam, anti-itching drugs such as glycerite lotion, etc. 1. Antihistamines: loratadine can relieve itching. 2. Bile acid chelating drugs: Kaureneamine is mainly through the combination with bile acid salt, inhibit its reabsorption, thus reducing the content of cholesterol and low-density lipoprotein, can be through the Kaureneamine to carry on the excretion of bile acid, relieve itching of the skin. 3. Antipruritic drugs: Glycerol lotion is a common antipruritic drug used in dermatology, which can avoid the formation of localized ulcers and localized blisters, and can relieve skin itching. If the effect of the drug is not good, you should go to the hospital in time for examination, under the guidance of the doctor to carry out effective treatment to avoid adverse consequences.