The most important principles of treatment for organophosphorus pesticide poisoning are removal of toxic substances, application of special antidotes, and symptomatic supportive treatment. Early gastric lavage can also reduce the absorption of toxic substances, and early and reasonable application of atropine, chlorophosphatidine, and iodophosphatidine can alleviate cholinergic excitation performance and central inhibition. Stabilization of vital signs is the basis for the efficacy of all therapeutic measures. Atropine is a potent antidote for organophosphorus poisoning, while reenergizers are the fundamental etiological treatment. The treatment principle of atropine is early, adequate and repeated application, until atropinization is achieved in order to relieve muscarinic-like symptoms; effective cholinesterase reenergizer application can reduce the dosage of atropine. In addition atropine should be gradually reduced in dosage reduction and the patient’s symptoms and vital signs should be observed.