Mast cell hyperplasia can be treated with general treatment, medication, and other treatments. Specific treatment methods need to go to the hospital under the guidance of the doctor to choose. 1. General treatment: patients with mast cell hyperplasia should avoid stimulation of the affected area, ensure that the skin around the affected area is clean and dry, and avoid vigorous scratching, clawing, friction and so on. Daily diet should be light, avoid spicy, stimulating, cold food, quit smoking and drinking. 2. medication: aspirin, antihistamines, proton pump inhibitors, etc., can also be used orally or externally glucocorticoids. 3. Other treatments: If the patient has a single skin lesion and the condition is serious, glucocorticoid drugs can be injected through the skin lesion, or the skin lesion can be removed through surgery. In recent years, biological agents also play an important role in the treatment of mast cell hyperplasia, such as midostaurin and imatinib. The use of the above medications should be under the guidance of a doctor, avoid self-medication. If the symptoms of the lesions are not relieved, or accompanied by other symptoms, you should go to the hospital in a timely manner, under the guidance of the doctor for treatment.