Patients with advanced bladder cancer have a low possibility of cure. Targeted therapy, immunotherapy and systemic chemotherapy can be adopted to prolong the survival period and improve the quality of life. 1. Targeted therapy: through tyrosinase inhibitor for advanced bladder cancer, it can reduce the distribution of blood vessels and nutrient supply in the tumor site, so as to shrink the tumor. It is highly targeted and has certain curative effect on liver cancer, kidney cancer and various reproductive tract tumors. 2. Immunotherapy: Immunotherapy includes monoclonal antibody immunotherapy, which can find the most suitable therapeutic drugs through genetic testing and thus control the development of the disease. 3. Systemic chemotherapy: systemic therapy can ease the pain of patients with advanced bladder cancer and prolong the survival time. Usually, there is no way to do radical radiotherapy at this time, and the efficacy is general and the side effects are relatively large. Although the possibility of cure for patients with advanced bladder cancer is relatively low, patients can still prolong their survival by keeping a good attitude and actively cooperating with doctors.