The pain of cholecystitis is aggravated by lying down mainly because lying down increases the irritation and compression effect of the abdominal wall on the gallbladder. When you have cholecystitis, bile excretion will be affected, and excessive bile storage will cause excessive contraction of the gallbladder wall as well as enlargement of the gallbladder, thus causing pain. When lying down, the gravity of the abdominal wall increases the pressure and irritation of the enlarged gallbladder, which can lead to increased cholecystitis pain. When standing, the abdominal wall usually does not have direct contact with the gallbladder, and pain symptoms may be slightly less severe than when lying flat. If the cholecystitis pain is aggravated by lying down, you need to go to the regular hospital in time for further examination, through ultrasound, CT and other tests, to clarify the cause of the disease in time, and actively cooperate with the doctor to carry out targeted treatment.