Closed pimples on the face can be removed clinically in a variety of ways, but due to the large individual differences, it is necessary to combine the individual situation and choose the appropriate method of treatment under the guidance of a doctor: i. Needle clearing: suitable for a small number of large pimples. It is performed by a professional in a sterile room, using sterile instruments in a sterile environment to puncture the pimples and squeeze out the secretions inside. The procedure usually does not bleed and the patient does not feel any pain. After the needle is cleared, red and blue light can be used to help reduce inflammation. Medication: 1. Topical medication: Suitable for patients with more acne. The creams for acne treatment mainly contain ingredients such as retinoic acid, commonly used are adapalene gel, tazarotene gel, retinoic acid cream and so on. Since retinoic acid is easy to decompose when exposed to light, it is recommended to use it at night and dab it on the acne lesions. 2. Oral medication: It is suitable for small, closed pimples that are not easy to apply medication. Commonly used drugs include isotretinoin capsules and vincristine capsules, which have the ability to regulate cellular keratinization and are more effective in the treatment of closed mouth acne. It is recommended to always choose a professional medical institution and treat under the guidance of a professional. Self-treatment may lead to scarring. In addition, closed pimples appear due to clogged pores caused by high oil secretion, so it is important to pay attention to good cleansing on a daily basis, which is more effective with the treatment.