The cure rate of giant cell tumor of bone varies mildly according to the severity of the disease and individual’s physical condition, and the surgical cure rate is about 70%. It can be treated by surgery or radiotherapy, but it is easy to recur, and the recurrence rate is 5~15%. The treatment of giant cell tumor of bone is mainly based on surgical resection, applying cut and scrape with inactivation treatment and implantation of autologous or allogeneic cancellous bone or bone cement. The recurrence rate of this disease is high, and for recurrence, resection or segmental amputation or prosthesis implantation should be performed. The disease is ineffective against chemotherapy. For those who are difficult to operate (e.g., spine), radiotherapy is available, and sarcomatoid transformation is likely to occur after radiotherapy. Giant cell tumor of bone is mainly treated by surgery, some patients have the possibility of postoperative recurrence, and those who have recurrence can undergo surgery again. For those who cannot be operated, radiotherapy can be carried out, but malignant transformation is easy to occur after radiotherapy. The surgical cure rate is about 70%. In recent years, surgical techniques have been improving, and it is believed that the cure rate will be higher and higher in the future. If diagnosed with Giant Cell Tumor of Bone, early and standardized treatment is recommended to reduce the adverse effects of the disease.