Under normal conditions, the regulation of the body temperature center keeps the body’s heat production and heat dissipation in a state of dynamic balance. When the body is infected by microorganisms such as viruses and bacteria the dynamic imbalance is lost, causing fever as well as sweating. Strenuous exercise and some autoimmune diseases can also cause fever. When the body is infected by external microorganisms, such as viruses and bacteria, the body produces endogenous pyrogens under microbial attack, which cause the thermoregulatory point of the body temperature center to rise, thus increasing the body’s heat production. In order to maintain body temperature balance, the human body needs to reduce heat production, enhance heat dissipation, and the main manifestation of heat dissipation that is the expansion of capillaries, sweat secretion increased, so the amount of sweating increased. In addition, strenuous exercise, some autoimmune diseases, wearing too thick or working in hot environments can also appear high body temperature, sweating. When there is a large amount of sweating after fever, water, sodium and other electrolytes should be replenished in a timely manner to prevent electrolyte disorders, dehydration and other abnormalities. If there are repeated occurrences of unexplained fever and sweating, you should consult a doctor in time and actively search for the cause. After a clear diagnosis, follow the doctor’s instructions to standardize the treatment.