Breastfeeding is an issue that women with epilepsy face immediately after delivery. Breast milk is nutritious, facilitates absorption and growth and development of the infant, and can make the infant more resistant to infection. However, many antiepileptic drugs can penetrate into breast milk through blood circulation, especially phenobarbital and benzodiazepines, which may cause drowsiness, weakness in sucking, slow weight gain, and in severe cases, respiratory distress and drug accumulation poisoning that can affect brain maturation after infants suck on them. Therefore, breastfeeding should take into account the mother’s wishes, the type, quantity and dosage of antiepileptic drugs and the condition of the newborn. The amount of antiepileptic drugs that the infant receives from the mother’s milk is very low, and most antiepileptic drugs, especially the newer antiepileptic drugs, have little effect on the infant, and in most cases it is safe for mothers taking antiepileptic drugs to breastfeed. However, when the infant develops some suspicious clinical symptoms after one to two weeks of receiving breast milk, such as lethargy, non-eating and immobility, and dyspnea, the infant’s blood levels need to be tested, and breastfeeding should be reduced and switched to artificial feeding. The mother should get enough sleep during breastfeeding to reduce nighttime sleep deprivation and prevent exacerbation of seizures. Someone needs to be present during breastfeeding to prevent injury to the infant due to seizures while breastfeeding.