Cough in the morning is more common diseases such as chronic bronchitis, bronchiectasis and lung abscess, etc. Cough in the evening is more common cough variant asthma, tuberculosis, parabronchial nodules and heart failure, etc. Corresponding diagnosis needs to be combined with the patient’s medical history, signs and relevant auxiliary examination. If the patient has a long history of smoking, morning cough is more obvious, the first thing to consider chronic bronchitis, can do chest CT or chest X-ray examination. Cough at night is more intense, or smell the irritating smell of cough significantly aggravated patients, the first consideration of cough variant asthma. Bronchial asthma is more likely, need to do pulmonary function tests or bronchodilator test, as well as bronchial excitation test for further clarification. For elderly patients with hypertension, diabetes and other underlying diseases, the emergence of nocturnal paroxysmal cough or dyspnea, we need to be vigilant for heart failure, need to improve the cardiac ultrasound and coronary artery angiography and other related tests to clarify.