High thyroid stimulating hormone in newborns is commonly caused by maternal factors or congenital hypothyroidism in newborns. Some newborns will contain antibodies from their mothers after birth, and low maternal nutrients may lead to high thyroid stimulating hormone in newborns, which can be cured on its own and usually does not have particularly obvious manifestations. If the newborn is suffering from congenital hypothyroidism or other causes of high thyroid hormone, there will be dry and rough skin, slow heart rate, prolonged jaundice, etc. If not treated in time, it will have a certain impact on the newborn’s growth and development, substance metabolism, brain development, and physical development in the later stage of life. Newborns with high thyroid stimulating hormone may also have other causes, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.