The domestic tofacitib has the same effect as the imported one. Tofacitib is used for rheumatoid arthritis treatment of drugs, belongs to the new oral protein tyrosine kinase inhibitors, domestic and imported drugs in the effect of the above gap is not big, mainly in the price of the existence of a big difference, relatively speaking, domestic tofacitib will be a lot lower, and imported because of the cost, tariffs and other effects, resulting in a higher price. Tofacitib mainly inhibits intracellular JAK signaling, reduces immune cell activation, pro-inflammatory cell shadow release, thus blocking the cascade amplification reaction of inflammation, the patient’s body of pro-inflammatory cytokines said the index is lowered, and play a role in the treatment of rheumatoid arthritis.