If the wrong medication is used, it does not have a significant impact on the heart, liver, kidneys, and other vital organs, and generally does not directly lead to a worsening of schizophrenia. However, failure to treat with the right medication in a timely manner will delay the treatment of the disease and the disease itself may continue to progress and worsen. If the schizophrenia condition is not effectively controlled or even worsens with medication, we should consider multiple factors rather than immediately discontinuing the medication. First, the condition should be reassessed and whether the diagnosis is correct should be considered. Second, whether the medication was used correctly, such as whether the dosage was adequate and whether the course of treatment was sufficient. Third, how well the patient is taking the medication, such as self-reduction of medication, irregular medication, etc. can also lead to poor drug treatment effect. Fourth, the presence of factors that interfere with drug metabolism, such as heavy smoking, taking carbamazepine and other drugs will also affect the efficacy of the drug. If the above-mentioned interfering factors are ruled out, but the effect is still poor, a gradual reduction of medication or a change to other drugs should be considered to continue treatment. Patients with schizophrenia who do not have good results with medication may consider MECT treatment.