Disorders of glucose metabolism are affected by physiologic, genetic, and pathological factors. Physiological factors of elevated blood glucose, such as obesity, cause insulin resistance leading to glucose metabolism disorders; genetic factors, such as diabetes mellitus has a certain heredity. Pathological factors, such as hyperthyroidism, pheochromocytoma, etc. will cause glucose metabolism disorder. Physiological factors of blood glucose lowering, such as eating less, long-term strenuous exercise leads to low blood glucose. Pathological factors, such as taking too much hypoglycemic drugs, neuroendocrine tumors, pancreatic islet ß-cell tumors, etc. can lead to lower blood glucose. Excessive blood glucose or recurrent hypoglycemia should be taken seriously, go to the hospital for a clear examination, and be treated with medication according to the doctor’s prescription.