Sildenafil and dapoxetine hydrochloride can be taken at the same time, there is no obvious contraindications between the two drugs, if there is also premature ejaculation as well as erectile dysfunction, it can be taken at the same time, but need to rule out the contraindications to their respective. Sildenafil is mainly used in the treatment of erectile dysfunction, and dapoxetine hydrochloride is currently approved for the treatment of premature ejaculation. If both premature ejaculation and erectile dysfunction are present, they can be taken at the same time. However, it is important to note that dapoxetine hydrochloride is contraindicated in people with a known allergy to the product, in patients with significant pathological conditions of the heart, and in patients with moderate and severe liver damage. The drug should also not be used in conjunction with thioridazine, strong cytochrome P450 3A4 inhibitors, and monoamine oxidase inhibitors. Sildenafil is prohibited in combination with nitrates, the drug is contraindicated in women, people who are allergic to the product, children, people whose recent cardiovascular state does not allow them to have sex. The use of dapoxetine hydrochloride can cause headache, dizziness, nausea, diarrhea and other adverse reactions, sildenafil tablets common adverse reactions are mainly headache, flushing, dizziness, nasal congestion, dyspepsia, visual abnormalities. Male patients who have both premature ejaculation and erectile dysfunction should go to the urology department or the male department, choose the appropriate medication under the guidance of the doctor, and should not take the medication without authorization, so as not to cause adverse drug reactions and side effects.