Heavy remodeling with atg treatment usually takes more than 3 months and the white blood cells will rise. Severe remodeling is heavy aplastic anemia, atg is anti-thymocyte globulin, belongs to the immunosuppressant, is the main treatment for some patients with severe remodeling who are not suitable for hematopoietic stem cell transplantation treatment. Generally, the white blood cells of patients with severe retroviral anemia will start to rise after 3 months of atg treatment, but some patients may need more than half a year to have the effect, and some patients may even have no sustained and obvious effect. Patients with no obvious effect or relapse can use the second course of treatment or undergo allogeneic hematopoietic stem cell transplantation. The atg treatment for severe remodeling should be carried out in regular hospitals, and the doctor should decide the treatment plan according to all the examination indexes.