The skull is one of the hardest bones in our body and plays an important role in protecting brain tissue and maintaining a stable intracranial environment, which is essential for normal life functioning. Therefore, if a cranial defect occurs, it should be repaired in a timely manner. In addition, the soft tissues inside the skull are not protected by the hard shell and may be easily damaged by external forces; secondly, the unstable intracranial pressure caused by skull defect may also affect the normal operation of intracranial life activities. The external manifestation is that it may lead to frequent headache and dizziness, in addition to the patient’s fear of pulsation, expansion and collapse of the defect area, as well as fear of sunlight, vibration and even noisy sound. It may also cause lack of concentration and memory loss, and some patients show depression, fatigue, reticence and low self-esteem. Therefore, it is very necessary to have skull repair surgery in time after skull defect. The detailed steps of skull repair surgery: first anesthesia, disinfection, then scalp incision, exposure of the bone window, preoperative three-dimensional shaped polyetheretherketone PEEK repair piece, according to the shape of the patient’s skull defect adjustment reset and fixed, suture scalp, surgery is completed. It is important to emphasize that not only is it important to standardize the detailed steps of cranial repair surgery, but also the material of cranial repair is important. The polyetheretherketone PEEK material we use is an excellent material, which can be shaped in three dimensions according to the patient’s skull data and highly restore the anatomical structure of the skull, and it has the same performance as the autologous skull in terms of elasticity, hardness, heat insulation, stability, etc. It has no rejection reaction and does not interfere with CT, MRI, etc. It is an excellent skull replacement material and has become the new favorite in the skull repair world. It is an excellent cranial bone replacement material and has become a new favorite in the field of cranial repair.