The price of O-type RH-negative blood is about 400 dollars for a bag of 2 units, and there is no significant difference between the price of O-type RH-negative blood and the price of O-type RH-positive blood, which is the same as that of O-type RH-positive blood. However, due to the relative rarity of O-type RH-negative people, O-type RH-negative blood often encounters difficulties in blood supply when blood is needed in the clinic. Because RH-negative people can only receive RH-negative blood, if they receive RH-positive blood, it will stimulate the body to produce obvious antibodies, and when they come into contact with RH-positive blood again, an antigen-antibody reaction will take place, leading to the lysis and destruction of red blood cells. The patient will experience a series of symptoms such as high fever, headache, low back pain, hematuria, urinary closure, and even acute renal failure and shock, which will jeopardize the patient’s life. So the price of O-type RH-negative blood, like that of positive blood, is around 400 dollars.