Sartan antihypertensive drugs can generally be taken with diphenhydramine, which can enhance the antihypertensive effect. Sartan antihypertensive drug belongs to angiotensin II receptor antagonist, diphenhydramine antihypertensive drug belongs to calcium channel blocker, there is generally no contraindication between the two drugs. 1. Sartan antihypertensive drugs and diphenhydramine antihypertensive drugs with, can effectively enhance the effect of antihypertensive, because the two types of different types of antihypertensive drugs, antihypertensive mechanism of different drugs with the use of the antihypertensive effect can enhance the efficacy of antihypertensive. 2. Sartan antihypertensive drugs and diphenhydramine antihypertensive drugs with also help to protect the kidneys, sartan drugs have to reduce urinary protein, protect the kidneys, and diphenhydramine can increase the blood supply of the kidneys, protect the kidney function. Combining the two drugs can reduce the adverse effects caused by a single drug dose. Although there are certain advantages of pairing sartan antihypertensive drugs with diphenhydramine antihypertensive drugs, they must be used strictly under the guidance of a doctor, not to mix and match without authorization, so as not to damage the body with the wrong medicine.