Characteristics of bronchial asthma

Features of bronchial asthma: Chronic airway inflammation, airway hyperresponsiveness, and airway reconstruction are the three main features of bronchial asthma. 1. Chronic airway inflammation: The basis of airway hyperresponsiveness, which is further exacerbated by airway reconstruction and can be the pathological basis of intractable asthma. Airway hyperresponsiveness causes loss of protection of the normal airway epithelium and exposes the submucosal sensory nerve endings. Inhaled allergens and chemicals may thus reach the submucosa directly and cause smooth muscle spasm via axonal reflexes, aggravating airway inflammation and further promoting airway reconstruction. 2.Airway hyperresponsiveness: It refers to a state of abnormal sensitivity of the airways and bronchi, showing an overly strong and premature response to various stimuli (physical, chemical, biological, etc.) factors. Airway smooth muscle cell hyperplasia and hypertrophy are directly related to airway hyperresponsiveness, and bronchospasm is the central link of airway hyperresponsiveness. 3, airway reconstruction: Asthma a characteristic pathological changes, including a series of pathological changes such as hyperplasia and hypertrophy of airway smooth muscle cells, epithelial cell proliferation, subepithelial fibrosis, remodeling of intercellular matrix after elastin destruction and increased vascular distribution. Airway reconstruction is a change in the structure of the asthmatic airway wall that has been gradually demonstrated in recent years in the development of airway inflammation theory, and is a pathomorphological feature of the chronic airway inflammation acting on the asthmatic airways, which is the pathological basis for the persistence of post-weather tract hyperresponsiveness. Therefore, reducing airway inflammation, decreasing airway hyperresponsiveness and preventing airway reconstruction become the focus of asthma prevention and treatment. Thus, it also provides an entry point for clinical and experimental research on anti-asthma recurrence in Chinese medicine.