Early symptoms of primary lateral sclerosis include: movement disorder, limb incoordination, difficulty in walking and so on. 1. Movement disorder: patients with primary lateral sclerosis, in the early stage of the disease, may cause some damage to the motor nerve fibers, which may cause the patient’s limbs to have movement disorders, mainly manifested as the affected side of the limbs are not flexible, the affected side of the limbs stiffness, paralysis and other symptoms. 2. Limb incoordination: the motor nerve of the patient is seriously affected, which may cause uncoordinated limb movement, limb spasm, and inability to carry out coordinated movement. 3. Difficulty in walking: Patients may have dystonia and hyperreflexia, causing difficulty in walking. When patients have the above symptoms, they should consult the doctor in time, improve the examination and standardize the treatment.