Ankylosing spondylitis may lead to sciatica, in which patients mainly experience pain and stiffness in the lower back or buttocks. Ankylosing spondylitis is a chronic inflammatory disease involving the spine, sacroiliac joints and other joints, which may affect the normal life of patients and even cause disability. The cause of ankylosing spondylitis is not yet clear, and it is mostly related to several factors such as heredity, infection, environment, etc. If you suffer from ankylosing spondylitis, you may experience sciatica. In the early stage of the disease, patients usually experience dull pain or morning stiffness in the lumbosacral region, which is mainly manifested as pain in the lower back, sacroiliac region and buttocks, and the symptoms are alleviated after activities. As the disease progresses, it develops from the lumbar spine to the thoracic and cervical spine, thus causing pain in the corresponding areas. If sciatic pain occurs, it is considered to be caused by ankylosing spondylitis, in addition, there is also the possibility of suffering from other diseases, such as sciatica, cervical spondylosis and so on. It is recommended that the patient consult a doctor in time for a clear diagnosis. Daily need to rest, avoid overwork, so as not to aggravate the discomfort.