The effectiveness of western medicine in treating atrophic gastric sinusitis needs to be treated by a doctor who chooses the right medicine according to the patient’s specific condition. The treatment of atrophic gastric sinusitis requires the removal of Helicobacter pylori, inhibition of gastric acid secretion, promotion of gastric motility, and protection of gastric mucosa. 1. Remove Helicobacter pylori: Carbon breath test first to determine whether there is Helicobacter pylori infection. If combined with H. pylori infection, it should be actively given quadruple therapy eradication treatment, i.e. a proton pump inhibitor (e.g., omeprazole) plus two antibiotics (e.g., amoxicillin, metronidazole) and a bismuth agent (e.g., bismuth potassium citrate). 2. Inhibit gastric acid: after removing H. pylori, drugs to inhibit gastric acid need to be used consistently, such as ranitidine. 3. Promote gastric power: patients with epigastric fullness and bile reflux can use drugs to promote gastric power, such as mosapride. 4. Protect the gastric mucosa: the gastric mucosa can be given to promote the proliferation of drugs, such as aluminum phosphate gel, colloidal bismuth pectin and so on. It is recommended that patients with atrophic gastro-sinusitis consult a doctor in a timely manner, complete the relevant examinations, and choose the appropriate drugs under the guidance of the doctor.