Thyroid ultrasound suggests that the uneven texture of the thyroid gland should first be identified as the cause, which may be due to toxic diffuse goiter, Hashimoto’s thyroiditis, thyroid nodules and other diseases, and should be treated according to the cause of the disease. 1. Toxic diffuse goiter: thyroid ultrasound suggests that the uneven texture of the thyroid gland may be caused by toxic diffuse goiter. Patients can take oral antithyroid drugs such as methimazole and propylthiouracil under doctor’s guidance, and radiation therapy is also available. If necessary, total thyroidectomy and subtotal thyroidectomy can be performed. 2. Hashimoto’s thyroiditis: thyroid ultrasound suggests that the uneven texture of the thyroid gland may also be due to Hashimoto’s thyroiditis. If the patient has no clinical symptoms and the thyroid function is normal, there is no need to take special treatment, and regular observation is sufficient. However, if combined with hypothyroidism, oral levothyroxine should be prescribed. 3. Thyroid nodules: thyroid ultrasound suggests that the uneven texture of the thyroid gland may also be caused by thyroid nodules. If the patient has benign nodules and has no symptoms, the patient can be observed for the time being. If malignant nodules are diagnosed, thyroid lobectomy and total thyroidectomy may be performed. There are many reasons for thyroid ultrasound to indicate uneven texture of the thyroid gland, and patients are advised to take treatment measures after the cause of the disease is clarified.