Most patients with thyroid nodules can be vaccinated with the new coronavirus vaccine, unless they have symptoms of hyperthyroidism or hypothyroidism, in which case the vaccine can be withheld until their condition has stabilized. The new coronavirus vaccine is not suitable for people who are allergic to the vaccine components or in the acute stage of the disease. Thyroid nodules are caused by the abnormal proliferation of thyroid cells, and simple thyroid nodules will not affect the production of antibodies to the vaccine or have a great impact on the body, so they can be vaccinated with the new coronavirus vaccine normally. Patients with hyperthyroidism or hypothyroidism who are in the acute phase of the disease may be more susceptible to infection if they receive the vaccine while taking medication, so the vaccination can be postponed. The new coronavirus is very contagious, and vaccination is an effective means of protection, so it is recommended that people who are healthy and eligible for vaccination receive the new coronavirus vaccine in a timely manner.