Coronary heart disease can not quit smoking can be treated by medication, rewarding smoking cessation discouragement. Coronary heart disease is a type of heart disease caused by atherosclerosis of the coronary arteries causing narrowing or occlusion of the lumen of the arteries, leading to myocardial ischemia, hypoxia or necrosis. Smokers blood carbon monoxide hemoglobin content increases, and nicotine plays the role of vasoconstriction, will lead to arterial wall hypoxia and damage to blood vessels, so that coronary heart disease aggravate the condition of the study shows that the prevalence of coronary heart disease in smokers is much higher than that of non-smokers. Coronary heart disease patients can not quit smoking first to understand the impact of smoking on their own body, clear pros and cons. In addition, doctors and family members should also be involved in the patient’s smoking cessation action, to give the patient rewarding discouragement to quit smoking, in addition to the use of drugs such as varenicline to help adults to quit smoking, this drug may lead to insomnia, headache, and other adverse reactions, be aware of the possible increase in the risk of suicide and other consequences. Patients with coronary artery disease need to follow the doctor’s advice and actively cooperate with the doctor to quit smoking, so as to avoid aggravating the condition.