High naive granulocytes are commonly seen in three conditions: the first is chronic granulocytic leukemia. It is a malignant clonal disease of hematopoietic stem cells, which results in an abnormally high number of leukocytes in the peripheral blood due to the massive disorderly proliferation of neutrophils and late granulocytes in the bone marrow and their release into the peripheral blood, of which, it is the predominantly high number of neutrophils and late granulocytes. The second type is acute myeloid leukemia. Due to the massive proliferation of leukemic cells in the bone marrow, it leads to a high number of naïve granulocytes in the peripheral blood, of which, primitive cells account for the majority. The third type is leukemia-like reaction. It is the appearance of infantile cells in the peripheral blood due to other diseases such as infections or tumors, which resemble the similar manifestations of leukemia. After the cause is removed, the excessive number of naïve granulocytes in the peripheral blood will gradually disappear.